Polymorphisms in Genes Coding for Cytokines, Mannose-Binding Lectin, Collagen Metabolism and Thrombophilia in Women with Cervical Insufficiency

Objective: To study the association between cervical insufficiency and single nucleotide polymorphisms in seven genes coding for proand anti-inflammatory cytokine-related factors, mannose-binding lectin 2 (MBL2) , collagen1α1 (COL1A1) , factor II and factor V Leiden genes. Methods: In a case-control study, potential maternal biomarkers for cervical insufficiency were investigated in 30 women with a history of second-trimester miscarriage or preterm birth due to cervical insufficiency and in 70 control women. Results: Homozygous carriers of the interleukin 6 (IL6) –174 genotype GG had an odds ratio (OR) of 3.1 [95% confidence interval (95% CI) 1.3–7.4, p = 0.01] and MBL2 genotypes coding for low or intermediate levels of plasma MBL had an OR of 3.3 (95% CI 1.2–9.0, p = 0.01) for cervical insufficiency compared with controls. Serum MBL levels were lower in women with cervical insufficiency than in controls (median 408 and 1,985 ng/ml, respectively, p < 0.01). Conclusions: Single nucleoReceived: July 9, 2014 Accepted after revision: March 11, 2015 Published online: June 17, 2015 Iben Sundtoft, MD, PhD Department of Obstetrics and Gynecology Aarhus University Hospital Palle Juul-Jensens Boulevard 99, DK–8200 Aarhus N (Denmark) E-Mail sundtoft @ dadlnet.dk © 2015 S. Karger AG, Basel 0378–7346/15/0811–0015$39.50/0